An Expeditious Approach for the Synthesis of Optically Active Allyl Alcohols

Chandrasekhar, S (1995) An Expeditious Approach for the Synthesis of Optically Active Allyl Alcohols Tetrahedron Letters, 36 (28). pp. 5071-5074. ISSN 00404039

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Official URL: http://doi.org/10.1016/00404-0399(50)09426-

Related URL: http://dx.doi.org/10.1016/00404-0399(50)09426-

Abstract

Aldehyde tosylhydrazones having an adjacent -isopropylidene group undergo a condensation-fragmentation process in the presence of alkyl magnesium and alkyllithium reagents to yield chiral allyl alcohols. Practical preparation of -(E)-allyl alcohols is described starting from aldehyde tosylhydrazones having adjacent --isopropylidene group.

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