Synthesis and structure revision of the myo-inositol monophosphatase inhibitor L-671,776

Falck, J.R. ; Reddy, K.Kishta ; Chandrasekhar, S. (1997) Synthesis and structure revision of the myo-inositol monophosphatase inhibitor L-671,776 Tetrahedron Letters, 38 (30). pp. 5245-5248. ISSN 00404039

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Official URL: http://doi.org/10.1016/S0040-4039(97)01146-5

Related URL: http://dx.doi.org/10.1016/S0040-4039(97)01146-5

Abstract

Concomitant deprotection/spiro-heteroannulation of 6 utilizing (EtO)3SiI was exploited for the asymmetric total synthesis of the title tetracyclic terpenoid whose structure was revised to 13. The structure of the L-671,776 was revised based on an asymmetric total synthesis utilizing (EtO)3SiI for the key deprotection/spiro-heteroannulation.

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