Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine

Mohanakumara, Patel ; Sreejayan, Nambiar ; Priti, Vaidayanathan ; Ramesha, Bheemanahally Thimmappa ; Ravikanth, Gudasalamani ; Ganeshaiah, Kotiganahalli Narayanagowda ; Vasudeva, Ramesh ; Mohan, John ; Santhoshkumar, Thankayyan Retnabai ; Mishra, Prabhu Dutt ; Ram, Viswakarma ; Uma Shaanker, Ramanan (2010) Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine Fitoterapia, 81 (2). pp. 145-148. ISSN 0367-326X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S03673...

Related URL: http://dx.doi.org/10.1016/j.fitote.2009.08.010


Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of several cyclin-dependent kinases (CDKs). Rohitukine was first reported from Amoora rohituka (0.083% dry weight) followed by that in Dysoxylum binectariferum (0.9% dry weight), both belonging to the family Meliaceae. Here, we report incredibly high yields of rohitukine (7% dry weight) in trees of D. binectariferum from the Western Ghats, India. Crude extracts of the tree were found to be highly effective against ovarian and breast cancer lines tested.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Dysoxylum binectariferum; Rohitukine; Anticancer Activity; Flavopiridol
ID Code:13141
Deposited On:11 Nov 2010 06:46
Last Modified:14 Feb 2011 09:30

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