Intramolecular copper(I)-catalyzed 1,3-dipolar cycloaddition of azido-alkynes: synthesis of triazolo-benzoxazepine derivatives and their biological evaluation

Chandrasekhar, Srivari ; Seenaiah, Mallikanti ; Kumar, Abhishek ; Reddy, Chada Raji ; Mamidyala, Suman Kumar ; Kumar, Chityal Ganesh ; Balasubramanian, Sridhar (2011) Intramolecular copper(I)-catalyzed 1,3-dipolar cycloaddition of azido-alkynes: synthesis of triazolo-benzoxazepine derivatives and their biological evaluation Tetrahedron Letters, 52 (7). pp. 806-808. ISSN 00404039

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Official URL: http://doi.org/10.1016/j.tetlet.2010.12.040

Related URL: http://dx.doi.org/10.1016/j.tetlet.2010.12.040

Abstract

Synthesis of a series of [1,2,3] triazolo [5,1-c] [1,4]benzoxazepine derivatives have been accomplished by the intramolecular Cu(I)-catalyzed cycloaddition of azido-alkynes derived from salicylaldehyde. The biological profile of these heterocyclic structural scaffolds toward anti-bacterial as well as anti-fungal activity has also been illustrated.

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