Chandrasekhar, S. ; Vijaykumar, B.V.D. ; Mahesh Chandra, B. ; Raji Reddy, Ch. ; Naresh, P. (2011) Flow chemistry approach for partial deuteration of alkynes: synthesis of deuterated taxol side chain Tetrahedron Letters, 52 (30). pp. 3865-3867. ISSN 00404039
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Official URL: http://doi.org/10.1016/j.tetlet.2011.05.042
Related URL: http://dx.doi.org/10.1016/j.tetlet.2011.05.042
Abstract
The partial deuteration of alkynes proceeds via a flow chemistry approach under Lindlar’s heterogeneous catalysis to provide cis-dideuterated olefins in good yields. Further, dideuterated olefin has been successfully utilized for Sharpless asymmetric dihydroxylation followed by Mitsunobu reaction for the synthesis of deuterated taxol side chain.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd |
| Keywords: | Flow chemistry;Partial deuteration;Sharpless asymmetric dihydroxylation;Deuterated taxol side chain |
| ID Code: | 131369 |
| Deposited On: | 06 Dec 2022 11:32 |
| Last Modified: | 06 Dec 2022 11:32 |
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