Chandrasekhar, Srivari ; Patro, Vidyavathi ; Reddy, Gangireddy Pavan Kumar ; Grée, René (2012) A ligand-free copper(II)-catalyzed three-component reaction in poly(ethylene glycol) medium: a versatile protocol for the preparation of selected 3-indole derivatives Tetrahedron Letters, 53 (46). pp. 6223-6225. ISSN 00404039
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Official URL: http://doi.org/10.1016/j.tetlet.2012.09.008
Related URL: http://dx.doi.org/10.1016/j.tetlet.2012.09.008
Abstract
An efficient and eco-friendly method has been developed for the synthesis of selected 3-indole derivatives via a copper-catalyzed condensation between indole, aldehydes, and malononitrile in polyethylene glycol. The reagent system (PEG solvent plus catalyst) could be recycled up to 5 times for reaction with the same aldehyde and it was used also with at least three different aldehydes successively. This multi-component reaction (MCR) occurs first through Knoevenagel condensation followed by Michael addition of indole.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd |
| Keywords: | PEGIndole;Multicomponent reaction;CopperEco-friendly |
| ID Code: | 131349 |
| Deposited On: | 06 Dec 2022 10:56 |
| Last Modified: | 06 Dec 2022 10:56 |
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