Total Syntheses of Isomeric Spiroacetal Marine Natural Products Attenols A and B

Kumar, Vemula Praveen ; Kavitha, Nerella ; Chandrasekhar, Srivari (2013) Total Syntheses of Isomeric Spiroacetal Marine Natural Products Attenols A and B European Journal of Organic Chemistry, 2013 (28). pp. 6325-6334. ISSN 1434193X

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Official URL: http://doi.org/10.1002/ejoc.201300703

Related URL: http://dx.doi.org/10.1002/ejoc.201300703

Abstract

The convergent total synthesis of two marine natural products, attenols A and B is achieved with excellent stereocontrol. The synthetic route is based on an enantio- and regioselective Sharpless dihydroxylation, palladium(0)-catalyzed reduction to form δ-hydroxy-1-enoates, stereoselective mCPBA-mediated epoxidation, and Julia–Kocienski olefination.

Item Type:Article
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ID Code:131338
Deposited On:06 Dec 2022 10:35
Last Modified:06 Dec 2022 10:35

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