Lavanya, Nadella ; Kiranmai, Nayani ; Mainkar, Prathama S. ; Chandrasekhar, Srivari (2015) A practical synthesis of C14–C26 fragment of anticancer drug, eribulin mesylate Tetrahedron Letters, 56 (29). pp. 4283-4285. ISSN 00404039
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Official URL: http://doi.org/10.1016/j.tetlet.2015.05.077
Related URL: http://dx.doi.org/10.1016/j.tetlet.2015.05.077
Abstract
High yielding synthesis of C14–C26 fragment of eribulin is achieved from commercially available R-(+)-citronellol and 1,4-butane diol utilizing the chirality of citronellol ‘methyl’ centre as C25, organocatalytic epoxidation to install C23 chirality and Sharpless asymmetric dihydroxylation to install chirality at C20 and C17.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd |
| ID Code: | 131317 |
| Deposited On: | 06 Dec 2022 10:05 |
| Last Modified: | 06 Dec 2022 10:05 |
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