Murthy, Akondi Srirama ; Chandrasekhar, Srivari (2015) Practical and stereoselective synthesis of [6,6,5]-tricyclic core (C1–C13) of eribulin mesylate Tetrahedron Letters, 56 (29). pp. 4280-4282. ISSN 00404039
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Official URL: http://doi.org/10.1016/j.tetlet.2015.05.074
Related URL: http://dx.doi.org/10.1016/j.tetlet.2015.05.074
Abstract
Fully functionalised [6,6,5]-tricyclic core (C1–C13) of eribulin is stereoselectively synthesized from d-mannose. This simple and practical approach involves Still and Gennari modification of HWE-reaction, Sharpless asymmetric dihydroxylation, and oxa-Micheal addition as key reactions.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd |
| Keywords: | Eribulin;Tricyclic corecis-Wittig olefination;Oxa-Micheal reaction |
| ID Code: | 131316 |
| Deposited On: | 06 Dec 2022 10:03 |
| Last Modified: | 06 Dec 2022 10:03 |
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