Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H

Lade, Dhanaji M. ; Pawar, Amit B. ; Mainkar, Prathama S. ; Chandrasekhar, Srivari (2017) Total Synthesis of Lamellarin D Trimethyl Ether, Lamellarin D, and Lamellarin H The Journal of Organic Chemistry, 82 (9). pp. 4998-5004. ISSN 0022-3263

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Official URL: http://doi.org/10.1021/acs.joc.7b00636

Related URL: http://dx.doi.org/10.1021/acs.joc.7b00636

Abstract

Total syntheses of three different lamellarins have been accomplished using a Ru(II)-catalyzed (3 + 2) annulation strategy to construct the central pyrrole ring. The striking features of this synthesis are the use of PEG-400 as a green solvent for the (3 + 2) annulation reaction and multiple catalytic reactions with excellent overall yield. The present route also enables the synthesis of various lamellarin analogues devoid of a B ring.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:131302
Deposited On:06 Dec 2022 09:40
Last Modified:06 Dec 2022 09:40

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