Conformational Analysis of a 20-Membered Cyclic Peptide Disulfide fromConus virgowith a WPW Segment: Evidence for an Aromatic-Proline Sandwich

Sonti, Rajesh ; Rao, K. N. Shashanka ; Chidanand, Sudarshan ; Gowd, Konkallu Hanumae ; Raghothama, Srinivasarao ; Balaram, Padmanabhan (2014) Conformational Analysis of a 20-Membered Cyclic Peptide Disulfide fromConus virgowith a WPW Segment: Evidence for an Aromatic-Proline Sandwich Chemistry - A European Journal, 20 (17). pp. 5075-5086. ISSN 0947-6539

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Official URL: http://doi.org/10.1002/Chem.201303687

Related URL: http://dx.doi.org/10.1002/Chem.201303687

Abstract

A snail sandwich: A new class of peptide with a single disulfide bond has been isolated and structurally characterised from the venom of the marine cone snail, Conus virgo. The Trp–Pro–Trp (WPW) motif imposes a strong conformational restraint on the cyclic disulfide as a result of the sandwiched aromatic–proline interactions

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Deposited On:06 Dec 2022 05:34
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