Gajula, Praveen Kumar ; Sharma, Shrikant ; Ampapathi, Ravi Sankar ; Chakraborty, Tushar Kanti (2013) Total synthesis of (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor Org. Biomol. Chem., 11 (2). pp. 257-260. ISSN 1477-0520
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Official URL: http://doi.org/10.1039/C2OB26533H
Related URL: http://dx.doi.org/10.1039/C2OB26533H
Abstract
The first total synthesis of (29S,37S)-malevamide E (1), a potent ion channel inhibitor, has been achieved in a convergent fashion involving Julia–Kocienski olefination, Urpi acetal aldol and Shiina macrolactonization reactions as the key steps. The strategy developed herein is amenable for the synthesis of the other possible isomers in search for the correct stereoisomer of the naturally occurring molecule.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry |
| ID Code: | 131120 |
| Deposited On: | 02 Dec 2022 11:08 |
| Last Modified: | 02 Dec 2022 11:08 |
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