Sunkari, Yashoda Krishna ; Pal, Chandan ; Reddy, Thota Jagadeshwar ; Chakraborty, Tushar Kanti (2014) 3′-Amino-5′-carboxymethyl-3′,5′-dideoxy nucleosides for the synthesis of fully amide-linked RNA mimics Tetrahedron, 70 (35). pp. 5455-5462. ISSN 00404020
Full text not available from this repository.
Official URL: http://doi.org/10.1016/j.tet.2014.06.119
Related URL: http://dx.doi.org/10.1016/j.tet.2014.06.119
Abstract
A convenient protocol is developed for the synthesis of 3′-[N-(fluorenylmethoxycarbonyl)-amino]-5′-carboxymethyl derivatives of all four natural ribonucleosides from cheap chiral pool compound glucose. Synthesis of fully amide-linked RNA analogues of small oligonucleotides containing, for the first time, all four nucleoside amino acids using standard solid phase Fmoc-chemistry is described.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd |
| Keywords: | Modified nucleosides;Nucleoside amino acids;Antisense therapeutics;Solid phase peptide synthesis;Amide-linked RNA |
| ID Code: | 131108 |
| Deposited On: | 02 Dec 2022 10:54 |
| Last Modified: | 02 Dec 2022 10:54 |
Repository Staff Only: item control page
