Singh, Nishant ; Pulukuri, Kiran Kumar ; Chakraborty, Tushar Kanti (2015) Formal synthesis of degraded sterol (+)-aplykurodinone-1 Tetrahedron, 71 (28). pp. 4608-4615. ISSN 00404020
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Official URL: http://doi.org/10.1016/j.tet.2015.05.026
Related URL: http://dx.doi.org/10.1016/j.tet.2015.05.026
Abstract
The formal synthesis of aplykurodinone-1 is accomplished starting from a suitably functionalized bicyclic lactone having the requisite cis-fused ring junction with a quaternary chiral center that was assembled following a Cp2TiCl-mediated radical cyclization protocol. Our synthetic route further elaborates implementation of Grubbs ring closing metathesis (RCM), Eschenmoser-Claisen rearrangement and iodolactonization reactions for the synthesis of the final tricyclic precursor of the target molecule.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd |
| Keywords: | Asymmetric Sharpless kinetic resolution;Cp2Ti(III)Cl, radical cyclization;Ring closing metathesis (RCM)Eschenmoser-Claisen rearrangement;Iodolactonization |
| ID Code: | 131101 |
| Deposited On: | 02 Dec 2022 10:34 |
| Last Modified: | 02 Dec 2022 10:34 |
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