Molecular biology and pathogenesis of hepatitis E virus

Chandra, Vivek ; Taneja, Shikha ; Kalia, Manjula ; Jameel, Shahid (2008) Molecular biology and pathogenesis of hepatitis E virus Journal of Biosciences, 33 (4). pp. 451-464. ISSN 0250-5991

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The hepatitis E virus (HEV) is a small RNA virus and the etiological agent for hepatitis E, a form of acute viral hepatitis. The virus has a feco-oral transmission cycle and is transmitted through environmental contamination, mainly through drinking water. Recent studies on the isolation of HEV-like viruses from animal species also suggest zoonotic transfer of the virus. The absence of small animal models of infection and efficient cell culture systems has precluded virological studies on the replication cycle and pathogenesis of HEV. A vaccine against HEV has undergone successful clinical testing and diagnostic tests are available. This review describes HEV epidemiology, clinical presentation, pathogenesis, molecular virology and the host response to HEV infection. The focus is on published literature in the past decade.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Hepatitis E; HEV; Molecular Virology; RNA Virus; Vaccine
ID Code:13082
Deposited On:11 Nov 2010 05:00
Last Modified:16 May 2016 22:18

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