Naganna, Nimmashetti ; Madhavan, Nandita (2013) Soluble and Reusable Poly(norbornene) Supports with High Loading Capacities for Peptide Synthesis Organic Letters, 15 (22). pp. 5870-5873. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol4029435
Related URL: http://dx.doi.org/10.1021/ol4029435
Abstract
Poly(norbornene) supports comprising solubilizing ethylene glycol units and multiple amino acid attachment sites have been developed for peptide synthesis. A variety of amino acids have been efficiently loaded (0.6-1.1 mmol/g) onto the support in high yields (83-98%). Several tripeptides have been synthesized in moderate-to-good overall yields (41-66%) using only 1.2 equiv of coupling reagents/amino acids, and the support could be efficiently recycled up to 3 times.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 130459 |
| Deposited On: | 25 Nov 2022 07:28 |
| Last Modified: | 25 Nov 2022 07:28 |
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