Balasubramanian, Ranganathan ; Iqbal, Hiba ; Vijaya Gopal, Rachana ; Baby, C (2014) Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity Indian Journal Of Pharmaceutical Education And Research, 47 (4). pp. 31-38. ISSN 0019-5464
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Official URL: http://doi.org/10.5530/ijper.47.4.5
Related URL: http://dx.doi.org/10.5530/ijper.47.4.5
Abstract
A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflammation with compound 4b being the most promising derivative.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to ijper |
| ID Code: | 130314 |
| Deposited On: | 24 Nov 2022 06:44 |
| Last Modified: | 24 Nov 2022 06:44 |
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