John Victor, Napoleon ; Sakthivel, Ramasamy ; Muraleedharan, Kannoth Manheri ; Karunagaran, Devarajan (2013) N-Substituted 1,2-Dihydroquinolines as Anticancer Agents: Electronic Control of Redox Stability, Assessment of Antiproliferative Effects, and Mechanistic Insights ChemMedChem . n/a-n/a. ISSN 1860-7179
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Official URL: http://doi.org/10.1002/cmdc.201300210
Related URL: http://dx.doi.org/10.1002/cmdc.201300210
Abstract
Redox chemotherapy: Antiproliferative activities of a series of N-substituted 1,2-dihydroquinolines capable of causing redox imbalance in cancer cells are presented. Detailed studies showed that these derivatives arrest the cell cycle in the G2/M phase and induce apoptosis through an intrinsic pathway characterized by loss of mitochondrial membrane potential, DNA fragmentation, cytochrome c release, and activation of caspases 9 and 3.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to John Wiley and Sons. |
| ID Code: | 130281 |
| Deposited On: | 24 Nov 2022 05:02 |
| Last Modified: | 24 Nov 2022 05:02 |
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