Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity

Hatial, Ishita ; Jana, Saibal ; Bisai, Shrabani ; Das, Manasmita ; Ghosh, Ananta Kumar ; Anoop, Anakuthil ; Basak, Amit (2014) Trienediynes on a 1,3,5-trisubstituted benzene template: a new approach for enhancement of reactivity RSC Advances, 4 (53). p. 28041. ISSN 2046-2069

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Official URL: http://doi.org/10.1039/C4Ra04794J

Related URL: http://dx.doi.org/10.1039/C4Ra04794J

Abstract

The synthesis of trienediynes based on a 1,3,5-trisubstituted benzene template is described. The presence of three adjacent enediyne moieties in the dendritic core exerted a cooperative effect to bring down the onset temperature for Bergman cyclization leading to increased DNA cleavage in a shorter time.

Item Type:Article
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ID Code:129963
Deposited On:05 Dec 2022 05:36
Last Modified:05 Dec 2022 05:36

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