Banerjee, Samya ; Dixit, Akanksha ; Shridharan, Radhika N. ; Karande, Anjali A. ; Chakravarty, Akhil R. (2014) Endoplasmic reticulumtargeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(iv) vitamin-B6 complex in visible light Chemical Communications, 50 (42). pp. 5590-5592. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/C4CC02093F
Related URL: http://dx.doi.org/10.1039/C4CC02093F
Abstract
An oxovanadium(IV) vitamin-B6 Schiff base complex, viz. [VO(HL)(acdppz)]Cl, having (acridinyl)dipyridophenazine (acdppz) shows specific localization to endoplasmic reticulum (ER) and remarkable apoptotic photocytotoxicity in visible light (400–700 nm) in HeLa and MCF-7 cancer cells (IC50 LT 0.6 μM) while being non-toxic in the dark and to MCF-10A normal cells (IC50 GT 40 μM).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry |
| ID Code: | 129873 |
| Deposited On: | 21 Nov 2022 09:43 |
| Last Modified: | 21 Nov 2022 09:43 |
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