Sarangi, Aditya Narayan ; Lohani, Mohtasim ; Aggarwal, Rakesh (2015) Proteome mining for drug target identification in Listeria monocytogenes strain EGD-e and structure-based virtual screening of a candidate drug target penicillin binding protein 4 Journal of Microbiological Methods, 111 . pp. 9-18. ISSN 01677012
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Official URL: http://doi.org/10.1016/j.mimet.2015.01.011
Related URL: http://dx.doi.org/10.1016/j.mimet.2015.01.011
Abstract
We used a combination of in-silico approaches to identify 168 promising drug targets in the proteome of a multidrug-resistant Listeria monocytogenes strain; of these, one (PBP4) was particularly promising. Virtual screening using it, followed by reverse docking, revealed four compounds namely NCI524121, CAP332797, NCI524136 and ZINC00518462 as good multi-target leads.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| Keywords: | Drug target; Proteome subtraction; Reverse docking; Virtual screening |
| ID Code: | 129630 |
| Deposited On: | 23 Nov 2022 11:17 |
| Last Modified: | 23 Nov 2022 11:17 |
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