Hepatic epithelioid hemangioendothelioma: A diagnostic pitfall in aspiration cytology

Mathur, SandeepR ; Gupta, SDatta ; Durgapal, Prashant ; Iyer, VenkateswaranK ; Das, ChandanJyoti ; Shalimar, ; Acharya, SubratK ; Gupta, Ruchika (2010) Hepatic epithelioid hemangioendothelioma: A diagnostic pitfall in aspiration cytology CytoJournal, 6 (1). p. 25. ISSN 1742-6413

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Official URL: http://doi.org/10.4103/1742-6413.58951

Related URL: http://dx.doi.org/10.4103/1742-6413.58951


Hepatic epithelioid hemangioendothelioma (EH) is a rare vascular neoplasm. An accurate radiologic diagnosis is usually difficult due to the presence of multiple nodules, simulating metastatic carcinoma. Though histologic features of this tumor are well described, cytologic reports of hepatic EH are very few in the available literature. We describe a case of a young healthy adult male who was found to have multiple hepatic masses on radiologic investigations. A guided fine needle aspiration demonstrated a poorly differentiated neoplasm. The diagnosis was made on core biopsy assisted by immunohistochemistry, which showed characteristic features of EH. He is doing well 14 months after diagnosis, without surgical excision or chemotherapy. An accurate diagnosis of hepatic EH on aspiration cytology requires an adequate specimen and awareness of its cytologic features, including discohesive atypical cells with intracytoplasmic lumina and intranuclear inclusions. Since this tumor is usually unresectable but has a favorable prognosis as compared to hepatocellular carcinoma, a correct diagnosis is essential for appropriate management and prognostication.

Item Type:Article
Source:Copyright of this article belongs to Cytopathology Foundation, Inc.
Keywords:Aspiration cytology, epithelioid hemangioendothelioma (EH), histopathology, immunohistochemistry, liver
ID Code:129045
Deposited On:22 Nov 2022 10:31
Last Modified:22 Nov 2022 10:31

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