Microcalorimetric evaluation of the in vitro compatibility of amoxicillin/clavulanic acid and ampicillin/sulbactam with ciprofloxacin

Chadha, R. ; Kashid, N. ; Jain, D. V. S. (2004) Microcalorimetric evaluation of the in vitro compatibility of amoxicillin/clavulanic acid and ampicillin/sulbactam with ciprofloxacin Journal of Pharmaceutical and Biomedical Analysis, 36 (2). pp. 295-307. ISSN 0731-7085

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S07317...

Related URL: http://dx.doi.org/10.1016/j.jpba.2004.06.003

Abstract

Solution calorimetric technique has been used to determine the compatibility of binary and ternary systems of ampicillin trihydrate (AMP), sulbactam sodium (SS), amoxicillin trihydrate (AM), potassium clavulanate (PC) and ciprofloxacin hydrochloride (CP). The enthalpy of solution (ΔsolH) were obtained over a wide range of composition in the pH range 2-9. For all the pure drugs the ΔsolH is endothermic in nature. The molar enthalpies of interaction of binary (ΔHbi.E) and ternary (ΔHter.E) mixtures of the drugs in aqueous buffers have been determined. The ΔHbi.E for all binary systems is negative and pH dependent (maximum pH 6-8) indicating the interaction among charged species of the drugs. In case of binary systems with CP the magnitude of ΔHbi.E indicate strong interactions. The variation and magnitude of ΔHbi.E for the systems is discussed in terms of hydrogen bonding and van der Waal's interaction in the solution. The interaction parameter for ternary systems (A) is positive indicating repulsive interaction among the drugs. The coefficients hi's calculated from Redlich-Kister equation for binary systems (ΔHbi.E) and ternary interaction parameter (A) were used to predict the compatibility of the marketed formulations in pH range studied.

Item Type:Article
Source:Copyright of this article belongs to American Association of Pharmaceutical Scientists.
Keywords:Ampicillin Trihydrate; Amoxicillin Trihydrate; Ciprofloxacin Hydrochloride; Enthalpy of Solution; Potassium Clavulanate; Solution Calorimetry; Sulbactum Sodium; Ternary Interaction Parameter
ID Code:12904
Deposited On:11 Nov 2010 08:28
Last Modified:03 Jun 2011 06:46

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