Single-molecule DNA sequencing technologies for future genomics research

Gupta, Pushpendra K. (2008) Single-molecule DNA sequencing technologies for future genomics research Trends in Biotechnology, 26 (11). pp. 602-611. ISSN 0167-7799

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S01677...

Related URL: http://dx.doi.org/10.1016/j.tibtech.2008.07.003

Abstract

During the current genomics revolution, the genomes of a large number of living organisms have been fully sequenced. However, with the advent of new sequencing technologies, genomics research is now at the threshold of a second revolution. Several second-generation sequencing platforms became available in 2007, but a further revolution in DNA resequencing technologies is being witnessed in 2008, with the launch of the first single-molecule DNA sequencer (Helicos Biosciences), which has already been used to resequence the genome of the M13 virus. This review discusses several single-molecule sequencing technologies that are expected to become available during the next few years and explains how they might impact on genomics research.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:12895
Deposited On:11 Nov 2010 08:30
Last Modified:16 May 2016 22:08

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