Assessment of liver fibrosis in chronic hepatitis: comparison of shear wave elastography and transient elastography

Paul, Shashi B. ; Das, Prasenjit ; Mahanta, Mousumi ; Sreenivas, Vishnubhatla ; Kedia, Saurabh ; Kalra, Nancy ; Kaur, Harpreet ; Vijayvargiya, Maneesh ; Ghosh, Shouriyo ; Gamanagatti, Shivanand R. ; Shalimar, ; Gupta, Siddhartha Dutta ; Acharya, Subrat K. (2017) Assessment of liver fibrosis in chronic hepatitis: comparison of shear wave elastography and transient elastography Abdominal Radiology, 42 (12). pp. 2864-2873. ISSN 2366-004X

Full text not available from this repository.

Official URL:

Related URL:


Purpose: To evaluate the diagnostic accuracy of shear wave elastography (SWE) and transient elastography (TE) in the evaluation of liver fibrosis in chronic hepatitis B (CHB) and C (CHC) patients taking liver biopsy as gold standard. Methods: Ethics committee approved this prospective cross-sectional study. Between October 2012 and December 2014, consecutive CHB/CHC patients fulfilling the inclusion criteria were included-age more than 18 years, informed written consent, willing and suitable for liver biopsy. SWE, TE, and biopsy were performed the same day. Liver stiffness measurement (LSM) cut-offs for various stages of fibrosis were generated for SWE and TE. AUC, sensitivity, specificity, and positive/negative predictive values were estimated individually or in combination. Results: CH patients (n = 240, CHB 172, CHC 68), 176 males, 64 females, mean age 32.6 ± 11.6 years were enrolled. Mean LSM of patients with no histological fibrosis (F0) was 5.0 ± 0.7 and 5.1+1.4 kPa on SWE and TE, respectively. For differentiating F2 and F3-4 fibrosis on SWE, at 7.0 kPa cut-off, the sensitivity was 81.3% and specificity 77.6%. For TE, at 8.3 kPa cut-off, sensitivity was 81.8% and specificity 83.1%. For F3 vs. F4, SWE sensitivity was 83.3% and specificity 90.7%. At 14.8 kPa cut-off, TE showed similar sensitivity (83.3%) but specificity increased to 96.5%. Significant correlation between SWE and TE was observed (r = 0.33, p < 0.001). On combining SWE and TE, a drop in sensitivity with increased specificity for all stages of liver fibrosis occured. Conclusion: SWE is an accurate technique for evaluating liver fibrosis. SWE compares favorably with TE especially for predicting advanced fibrosis/cirrhosis. Combining SWE and TE further improves specificity.

Item Type:Article
Source:Copyright of this article belongs to Springer Nature
Keywords:Chronic hepatitis; Diagnostic accuracy; Liver fibrosis; Shear wave elastography; Transient elastography
ID Code:128825
Deposited On:21 Nov 2022 11:41
Last Modified:21 Nov 2022 11:42

Repository Staff Only: item control page