Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Annulation of Modified Enals with Enolizable Aldehydes

Yetra, Santhivardhana Reddy ; Kaicharla, Trinadh ; Kunte, Sunita S. ; Gonnade, Rajesh G. ; Biju, Akkattu T. (2013) Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Annulation of Modified Enals with Enolizable Aldehydes Organic Letters, 15 (20). pp. 5202-5205. ISSN 1523-7060

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Official URL: http://doi.org/10.1021/ol4026155

Related URL: http://dx.doi.org/10.1021/ol4026155

Abstract

N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the α,β-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.

Item Type:Article
Source:Copyright of this article belongs to American Chemical Society
ID Code:128693
Deposited On:03 Nov 2022 06:54
Last Modified:03 Nov 2022 06:54

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