Roy, Tony ; Baviskar, Dnyaneshwar R. ; Biju, Akkattu T. (2015) Synthesis of N-Aryl β-Amino Alcohols by Trifluoroacetic Acid Promoted Multicomponent Coupling of Aziridines, Arynes, and Water The Journal of Organic Chemistry, 80 (21). pp. 11131-11137. ISSN 0022-3263
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Official URL: http://doi.org/10.1021/acs.joc.5b01798
Related URL: http://dx.doi.org/10.1021/acs.joc.5b01798
Abstract
A transition-metal-free, three-component coupling involving N-substituted aziridines, arynes, and water promoted by trifluoroacetic acid (TFA) has been reported. The reaction furnished medicinally important N-aryl β-amino alcohol derivatives in moderate to good yields. In addition, the use of azetidines in this reaction afforded N-aryl γ-amino alcohol derivatives.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 128672 |
| Deposited On: | 03 Nov 2022 06:51 |
| Last Modified: | 03 Nov 2022 06:51 |
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