Bhojgude, Sachin Suresh ; Baviskar, Dnyaneshwar R. ; Gonnade, Rajesh G. ; Biju, Akkattu T. (2015) Three-Component Coupling Involving Arynes, Aromatic Tertiary Amines, and Aldehydes via Aryl–Aryl Amino Group Migration Organic Letters, 17 (24). pp. 6270-6273. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/acs.orglett.5b03319
Related URL: http://dx.doi.org/10.1021/acs.orglett.5b03319
Abstract
The transition-metal-free multicomponent coupling of arynes, aromatic tertiary amines, and aldehydes proceeding via the aryl to aryl amino group migration has been demonstrated. This protocol allows rapid access to ortho-functionalized tertiary amines in moderate to good yields. Moreover, activated ketones can also be used as the aldehyde component in the present reaction. The similarity of the aryl-aryl tertiary amino group migration with the Smiles rearrangement is striking.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society |
| ID Code: | 128668 |
| Deposited On: | 03 Nov 2022 06:52 |
| Last Modified: | 03 Nov 2022 06:52 |
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