Hoffman, Thomas J. ; Dash, Jyotirmayee ; Rigby, James H. ; Arseniyadis, Stellios ; Cossy, Janine (2009) ChemInform Abstract: Enantioselective Organocatalytic Conjugate Reduction of β-Azole-Containing α,β-Unsaturated Aldehydes. ChemInform, 40 (46). pp. 2756-2759. ISSN 0931-7597
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Official URL: http://doi.org/10.1002/chin.200946133
Related URL: http://dx.doi.org/10.1002/chin.200946133
Abstract
Beta-azole-containing alpha,beta-unsaturated aldehydes were successfully reduced under highly enantioselective organocatalytic transfer hydrogenation conditions. The products were obtained in good yields and up to 94% optical purity. This simple process was successfully applied to the synthesis of the C7-C14 fragment of ulapualide A, a natural product which exhibits promising antitumor activity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to National Library of Medicine. |
| ID Code: | 128376 |
| Deposited On: | 19 Oct 2022 11:52 |
| Last Modified: | 19 Oct 2022 11:52 |
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