Calcium binding properties of beta-crystallins

Sharma, Yogendra ; Balasubramanian, D. (1996) Calcium binding properties of beta-crystallins Ophthalmic Research, 28 (Suppl.1). pp. 44-47. ISSN 0030-3747

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Related URL: http://dx.doi.org/10.1159/000267942

Abstract

β-Crystallins, the oligomeric proteins of the eye lens, were found to bind calcium ions with low affinity, in the millimolar range. Calcium was found to induce conformational changes in the secondary and tertiary structure of β-crystallins. While these changes in conformation are seen in low ionic strength media, they are masked when the protein is dissolved in an intermediate ionic strength medium, where oligomers of lower molecular weight are formed. The calcium binding takes place in these conditions. The behaviour of this protein with respect to calcium binding is reviewed.

Item Type:Article
Source:Copyright of this article belongs to Karger Publisher.
Keywords:Calcium Binding; Crystalline; Cataract
ID Code:1266
Deposited On:04 Oct 2010 07:58
Last Modified:13 May 2011 07:27

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