G-quadruplex recognition by bis-indole carboxamides

Dash, Jyotirmayee ; Shirude, Pravin S. ; Balasubramanian, Shankar (2008) G-quadruplex recognition by bis-indole carboxamides Chemical Communications (26). p. 3055. ISSN 1359-7345

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Official URL: http://doi.org/10.1039/B806042H

Related URL: http://dx.doi.org/10.1039/B806042H

Abstract

Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.

Item Type:Article
Source:Copyright of this article belongs to Royal Society of Chemistry.
ID Code:126526
Deposited On:17 Oct 2022 05:53
Last Modified:17 Oct 2022 05:53

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