Tewari, Debanjan ; Ahmed, Tofayel ; Chirasani, Venkat R. ; Singh, Pradeep K. ; Maji, Samir K. ; Senapati, Sanjib ; Bera, Amal Kanti (2015) Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848 (1). pp. 151-158. ISSN 00052736
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Official URL: http://doi.org/10.1016/j.bbamem.2014.10.014
Related URL: http://dx.doi.org/10.1016/j.bbamem.2014.10.014
Abstract
Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced conductance when treated with curcumin. Curcumin interacts with residues in the α helical N-terminus of VDAC and in the channel wall, as revealed by molecular docking, followed by mutational analysis. N-terminus mimicking peptide showed conformational changes in circular dichroism, upon curcumin treatment. We propose that the interaction of curcumin with amino acids in N-terminus and in channel wall fixes the α helix in closed conformation. This restricts its movement which is required for the opening of the channel.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V |
| ID Code: | 126502 |
| Deposited On: | 31 Oct 2022 04:18 |
| Last Modified: | 31 Oct 2022 04:18 |
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