GPCR Signaling: The Interplay of Gαi and β-arrestin

Dwivedi, Hemlata ; Baidya, Mithu ; Shukla, Arun K. (2018) GPCR Signaling: The Interplay of Gαi and β-arrestin Current Biology, 28 (7). R324-R327. ISSN 09609822

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Official URL: http://doi.org/10.1016/j.cub.2018.02.027

Related URL: http://dx.doi.org/10.1016/j.cub.2018.02.027

Abstract

Biased agonism at G-protein-coupled receptors is generally conceptualized as the ability of certain stimuli to trigger downstream signaling exclusively through one of two effectors. Recent studies reveal that signaling downstream of the β1 adrenergic receptor and the angiotensin II type 1 receptor induced by biased stimuli actually involves both effectors.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Ltd.
ID Code:126435
Deposited On:13 Oct 2022 06:06
Last Modified:13 Oct 2022 06:06

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