Fu, Li ; Das Sarma, Jayasri ; Lavi, Ehud (2001) Differential Expression of Tumor Necrosis Factor in Primary Glial Cell Cultures Infected with Demyelinating and Non-Demyelinating MHVs Advances in Experimental Medicine and Biology, 494 . pp. 663-668. ISSN 0065-2598
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Official URL: http://doi.org/10.1007/978-1-4615-1325-4_98
Related URL: http://dx.doi.org/10.1007/978-1-4615-1325-4_98
Abstract
TNF-α is a monocyte/macrophage derived cytokine with multiple biological activities that are antitumorigenic, cytotoxic, and pro-inflammatory in nature. TNF-α mediates cellular response through two distinct cell surface receptors, TNF-Rl(p55) and TNF-R2(p75) (Barbara et al 1996). TNF-α appears to have a diverse range of functions in the CNS due to its effect on astrocytes and oligodendrocytes. These include: induction of MHC class I Ag on astrocytes (Lavi et al 1988; Mauerhoff et al 1988), induction of ICAM-1, up-regulation of MHC class II Ag induced by IFN-γ and/or virus on astrocytes, stimulation of IL-6 secretion by astrocytes, myelin damage (Selmaj and Raine 1988) and lysis of oligodendrocytes (Robbins et al 1987).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Springer Nature Switzerland AG. |
| Keywords: | Major Histocompatibility; Complex Class; Post Infection; Astrocyte Culture; Mouse Hepatitis Virus; Mouse Astrocyte |
| ID Code: | 126398 |
| Deposited On: | 17 Oct 2022 06:13 |
| Last Modified: | 17 Oct 2022 06:13 |
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