Sarma, Jayasri Das ; Ciric, Bogoljub ; Marek, Ryan ; Sadhukhan, Sanjoy ; Caruso, Michael L ; Shafagh, Jasmine ; Fitzgerald, Denise C ; Shindler, Kenneth S ; Rostami, AM (2009) Functional interleukin-17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis Journal of Neuroinflammation, 6 (1). ISSN 1742-2094
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Official URL: http://doi.org/10.1186/1742-2094-6-14
Related URL: http://dx.doi.org/10.1186/1742-2094-6-14
Abstract
Background: Interleukin-17A (IL-17A) is the founding member of a novel family of inflammatory cytokines that plays a critical role in the pathogenesis of many autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). IL-17A signals through its receptor, IL-17RA, which is expressed in many peripheral tissues; however, expression of IL-17RA in the central nervous system (CNS) and its role in CNS inflammation are not well understood.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to PMC. |
| ID Code: | 126327 |
| Deposited On: | 17 Oct 2022 06:17 |
| Last Modified: | 19 Oct 2022 10:25 |
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