Sarma, Parishmita ; Banerjee, Ramanuj ; Shukla, Arun K. (2022) Structural snapshot of a β-arrestin-biased receptor Trends in Pharmacological Sciences . ISSN 01656147 (In Press)
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Official URL: http://doi.org/10.1016/j.tips.2022.08.005
Related URL: http://dx.doi.org/10.1016/j.tips.2022.08.005
Abstract
Atypical chemokine receptor subtype 3 (ACKR3), a chemokine receptor, couples selectively to β-arrestins (βarrs) but not to G proteins despite having seven transmembrane (7TM) helix architecture. Yen et al. present cryogenic-electron microscopy (cryo-EM) structures of agonist-bound ACKR3, elucidating a distinct chemokine-binding mechanism, and offering a structural template to probe the transducer-coupling bias at this receptor.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Ltd. |
| Keywords: | ACKR3; ACRs; GPCRs; biased agonism; chemokines; intrinsic bias; β-arrestins |
| ID Code: | 126316 |
| Deposited On: | 13 Oct 2022 05:50 |
| Last Modified: | 13 Oct 2022 05:50 |
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