Madhuri, Vrisha ; Ramesh, Sowmya ; Varma, Harikrishna ; Sivadasan, Suresh Babu ; Sahoo, Bibhudatta ; John, Annie (2020) First Report of a Tissue-Engineered Graft for Proximal Humerus Gap Non-union After Chronic Pyogenic Osteomyelitis in a Child JBJS Case Connector, 10 (1). e0031-e0031. ISSN 2160-3251
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Official URL: http://doi.org/10.2106/JBJS.CC.19.00031
Related URL: http://dx.doi.org/10.2106/JBJS.CC.19.00031
Abstract
Case: An 11-year-old child who presented with a postseptic gap nonunion of 4 cm in the proximal humerus was treated with a customized hydroxyapatite-tricalcium phosphate-tricalcium silicate composite (HASi) scaffold loaded with culture-expanded autologous bone marrow-derived mesenchymal stem cells (MSCs) primed into osteogenic lineage. Union occurred at 3 months, and at 3 years, the child had improved joint mobility, with radiographic and computed tomographic imaging evidence of incorporation of the graft. Conclusions: This case demonstrated the feasibility of MSC directed into osteogenic lineage on HASi to repair a long bone defect owing to postseptic osteomyelitis, a condition notorious for a high failure rate.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to The Journal of Bone and Joint Surgery, Inc. |
| ID Code: | 124109 |
| Deposited On: | 04 Nov 2021 04:56 |
| Last Modified: | 04 Nov 2021 04:56 |
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