Matcha, Kiran ; Ghosh, Subrata (2008) A stereocontrolled approach for the synthesis of 2,5-diaryl-3,4-disubstituted furano lignans through a highly diastereoselective aldol condensation of an ester enolate with an α -chiral center: total syntheses of (-)-talaumidin and (-)-virgatusin Tetrahedron Letters, 49 (21). pp. 3433-3436. ISSN 0040-4039
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...
Related URL: http://dx.doi.org/10.1016/j.tetlet.2008.03.105
Abstract
A general stereocontrolled approach for entry into a family of highly biologically active 2,5-diaryl-3,4-disubstituted furano lignans has been developed. The key step involves a diastereoselective aldol-type condensation of an ester enolate having an α-chiral center with an aromatic aldehyde. The methodology has been illustrated with the total syntheses of (-)-talaumidin and (-)-virgatusin.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Aldol Reaction; Enantiospecific; Lignans; Stereocontrol |
| ID Code: | 12379 |
| Deposited On: | 10 Nov 2010 06:19 |
| Last Modified: | 12 Feb 2011 11:05 |
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