Supramolecular Synthon Approach in Designing Molecular Gels for Advanced Therapeutics

Dastidar, Parthasarathi ; Roy, Rajdip ; Parveen, Rumana ; Sarkar, Koushik (2018) Supramolecular Synthon Approach in Designing Molecular Gels for Advanced Therapeutics Advanced Therapeutics, 2 (1). p. 1800061. ISSN 2366-3987

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Low-molecular-weight gelators (LMWGs) are an important class of soft materials that offer various potential applications including drug delivery. Structural diversities of the reported LMWGs and lack of molecular-level understanding of the self-assembly process of gelation make it difficult to design a gelator a priori. Most often gelators are discovered in a serendipitous manner and second-generation gelators are designed by modifying known gelling scaffolds. Since gel network within which the solvent molecules are immobilized is often found to be crystalline, a supramolecular synthon approach in the context of crystal engineering is demonstrated to be quite effective in designing LMWGs for various applications including therapeutics. Self-drug-delivery systems, wherein the need for a delivery vehicle does not exist, are becoming an effective alternative to conventional drug delivery systems. In the form of a simple gel (for non-invasive topical application) or injectable gel (for invasive subcutaneous applications), LMWGs derived from drugs provide an effective way to develop self-drug-delivery systems. This review article encompasses the early development of LMWG research, describes gradual transition from discovering just a gelator to a gelator having potential material applications including drug delivery, and highlights the merit of supramolecular synthon approach in designing LMWGs for self-drug-delivery applications.

Item Type:Article
Source:Copyright of this article belongs to John Wiley & Sons, Inc.
ID Code:123662
Deposited On:10 Oct 2021 10:10
Last Modified:10 Oct 2021 10:10

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