Dinda, Soumik ; Sarkar, Saheli ; Das, Prasanta Kumar (2018) Glucose oxidase mediated targeted cancer-starving therapy by biotinylated self-assembled vesicles Chemical Communications, 54 (71). pp. 9929-9932. ISSN 1359-7345
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Official URL: http://doi.org/10.1039/C8CC03599G
Related URL: http://dx.doi.org/10.1039/C8CC03599G
Abstract
Herein, we demonstrate glucose oxidase (GOx) mediated targeted cancer-starving therapy by self-assembled vesicle of trimesic acid based biotinylated amphiphile (TMB). The TMB vesicles entrapped GOx and selectively killed cancer cells (HeLa, B16F10), with ∼6-fold higher efficiency compared to non-cancer cells (CHO, NIH3T3), by blocking the energy supply to tumors through the oxidation of intracellular glucose.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Royal Society of Chemistry. |
| ID Code: | 123609 |
| Deposited On: | 08 Oct 2021 05:34 |
| Last Modified: | 08 Oct 2021 05:34 |
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