Enantiodivergent synthesis of (-)-methylenolactocin and (+)-methylenolactocin from D-mannitol

Ghosh, Manju ; Bose, Sritama ; Maity, Soumitra ; Ghosh, Subrata (2009) Enantiodivergent synthesis of (-)-methylenolactocin and (+)-methylenolactocin from D-mannitol Tetrahedron Letters, 50 (50). pp. 7102-7104. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2009.10.011


An enantiodivergent synthesis of both enantiomers of methylenolactocin is described through stereocontrolled addition of n-pentyl magnesium bromide to two D-mannitol-derived diastereomerically related aldehydes having an α-chiral center with a β hetero atom.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Anti-tumor Compounds; Asymmetric Synthesis; Lactone; Stereocontrol
ID Code:12359
Deposited On:10 Nov 2010 06:23
Last Modified:12 Feb 2011 10:34

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