Sahu, Arvind ; Lambris, John D (2002) Original article: Cardiovascular: Invited commentary Annals of Thoracic Surgery, 74 (2). p. 362. ISSN 0003-4975
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Official URL: http://doi.org/10.1016/S0003-4975(02)03751-7
Related URL: http://dx.doi.org/10.1016/S0003-4975(02)03751-7
Abstract
The complement system, an integral component of innate immunity, is the first line of immunological defense against foreign pathogens. Although it is designed to target pathogens and is tightly regulated by a series of complement inhibitors, excessive activation and failure in the intrinsic regulation of the complement system result in tissue injury [1]. This injury is directly mediated by the membrane attack complex and indirectly by the anaphylatoxins (C3a, C4a, and C5a) through their effects on neutrophils, eosinophils, and mast cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Society of Thoracic Surgeons. |
| ID Code: | 123320 |
| Deposited On: | 13 Sep 2021 10:23 |
| Last Modified: | 13 Sep 2021 10:23 |
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