Rit, Raja K. ; Yadav, M. Ramu ; Sahoo, Akhila K. (2014) Pd(II)-Catalyzed ortho-C–H Oxidation of Arylacetic Acid Derivatives: Synthesis of Benzofuranones Organic Letters, 16 (3). pp. 968-971. ISSN 1523-7060
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Official URL: http://doi.org/10.1021/ol403699d
Related URL: http://dx.doi.org/10.1021/ol403699d
Abstract
Pd(II)-catalyzed ortho-C–H acetoxylation of arylacetic acid derivatives is demonstrated with the aid of a novel S-methyl-S-2-pyridylsulfoximine (MPyS) directing group (DG). The α-mono- and α-unsubstituted arylacetic acid derivatives were readily employed in the ortho-C–H acetoxylations. The oxidation products are hydrolyzed, and the MPyS-DG is easily recovered, providing ready access to o-hydroxyarylacetic acids. 3-Mono- and 3-unsubstituted benzofuranones are synthesized from o-hydroxyarylacetic acids.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 122449 |
| Deposited On: | 02 Aug 2021 14:54 |
| Last Modified: | 02 Aug 2021 14:54 |
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