Antibodies to Arvin following prolonged intravenous therapy

Sapru, R. P. ; Moza, A. K. ; Kumar, M. ; Ganguly, N. K. (1975) Antibodies to Arvin following prolonged intravenous therapy Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis, 7 (4). pp. 635-641. ISSN 0049-3848

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Intravenous administration of Arvin in rabbits over a period of two months produced antibodies with consequent neutralisation of its action and a rise in fibrinogen concentration of blood to control values. The antibodies could be detected by the end of four weeks of therapy and were found to be a mixture of lgG and lgM class of immunoglobulins. The results indicate that prolonged Arvin therapy in clinical disorders may not be possible because of the antibody response to the drug.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:12201
Deposited On:10 Nov 2010 04:39
Last Modified:31 May 2011 11:33

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