Siva Swaroop, Pandrangi ; Raut, Gajanan N. ; Gonnade, Rajesh G. ; Verma, Priyanka ; Gokhale, Rajesh S. ; Srinivasa Reddy, D. (2012) Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues Organic and Biomolecular Chemistry, 10 (28). p. 5385. ISSN 1477-0520
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Official URL: http://doi.org/10.1039/C2OB25831E
Related URL: http://dx.doi.org/10.1039/C2OB25831E
Abstract
First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H37Rv).
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to The Royal Society of Chemistry |
| ID Code: | 121996 |
| Deposited On: | 27 Jul 2021 08:47 |
| Last Modified: | 27 Jul 2021 08:47 |
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