Effect of nifedipine treatment on oxidative metabolism of peritoneal macrophages and neutrophils of Plasmodium berghei-infected mice

Kalra, Anju ; Dubey, M. L. ; Ganguly, N. K. ; Mohan, K. ; Mahajan, R. C. (1992) Effect of nifedipine treatment on oxidative metabolism of peritoneal macrophages and neutrophils of Plasmodium berghei-infected mice Experimental Parasitology, 74 (1). pp. 20-26. ISSN 0014-4894

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/001448...

Related URL: http://dx.doi.org/10.1016/0014-4894(92)90135-W

Abstract

The oxidative metabolism of peritoneal macrophages (PM) and neutrophils from nifedipine (calcium channel blocker)-treated, Plasmodium berghei (NK 65)-infected and normal infected Swiss Albino mice was studied. A significant fall in oxidative metabolism as evidenced by decreased chemiluminescence (CL) response (P < 0.001) was recorded both in PM and neutrophils from nifedipine-treated mice compared to the control animals. When the oxidative metabolism of these phagocytes was studied after infection of the host, higher CL response was recorded from both PM and neutrophils isolated during the early course of infection (0-1 and 5-10% parasitaemia) when compared to uninfected mice (P < 0.001). A similar pattern was observed in the case of nifedipine-treated and infected mice even though the CL response was much lower. The increasing parasite load not only resulted in subnormal CL response but also prolonged the time required for the phagocytes to exhibit peak oxidative activity both in normal infected and CCB-treated infected mice, but the time taken to show peak CL response was shortened following drug administration compared to controls. These observations revealed the profound in vivo effect of CCB on the functioning of phagocytic leucocytes and thereby questions the use of CCB in combination with chloroquine for reversal of drug resistance.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Plasmodium berghei; Malaria; Mice; Neutrophil; Nifedipine; Latex
ID Code:12198
Deposited On:13 Nov 2010 13:29
Last Modified:31 May 2011 11:15

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