Gupta, Anu ; Sharma, V. K. ; Vohra, Harpreet ; Ganguly, N. K. (1999) Spontaneous apoptosis in peripheral blood mononuclear cells of leprosy patients: role of cytokines FEMS Immunology and Medical Microbiology, 24 (1). pp. 49-55. ISSN 0928-8244
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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1574-...
Related URL: http://dx.doi.org/10.1111/j.1574-695X.1999.tb01264.x
Abstract
Peripheral blood mononuclear cells from leprosy patients underwent spontaneous apoptosis upon culture for 24 h. The apoptosis was inhibited by anti-TNFα antibodies and to a certain extent by anti-IL-1α and IL-6, thus showing that TH2-type cytokines (mainly TNFα) are responsible for inducing apoptosis. This cytokine-mediated apoptosis could be inhibited by ionomycin and zinc, thereby suggesting that these metal ions can be used to decrease the levels of these inflammatory cytokines in various diseases.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Federation of European Microbiological Societies. |
| Keywords: | Apoptosis; Ionomycin; Zinc; Cytokine; Co-stimulatory Molecule |
| ID Code: | 12196 |
| Deposited On: | 10 Nov 2010 04:34 |
| Last Modified: | 16 May 2016 21:35 |
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