Swaroop, Pandrangi Siva ; Tripathy, Sibanarayan ; Jachak, Gorakhnath ; Reddy, D. Srinivasa (2014) Efforts towards the synthesis of microsporin B: ready access to both the enantiomers of the key amino acid fragment Tetrahedron Letters, 55 (34). pp. 4777-4779. ISSN 0040-4039
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Official URL: http://doi.org/10.1016/j.tetlet.2014.06.093
Related URL: http://dx.doi.org/10.1016/j.tetlet.2014.06.093
Abstract
Both the isomers methyl-(2S,8R)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate and methyl-(2S,8S)-2-((tert-butoxycarbonyl)amino)-8-hydroxydecanoate of an unusual amino acid residue and the key fragment of microsporin B are prepared. The key steps include cross metathesis and enzymatic kinetic resolution. In addition, a linear tetrapeptide with desired components towards total synthesis is also reported.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier B.V. |
| ID Code: | 121956 |
| Deposited On: | 23 Jul 2021 10:12 |
| Last Modified: | 30 Jul 2021 08:10 |
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