Vasudevan, N. ; Jachak, Gorakhnath R. ; Reddy, D. Srinivasa (2015) Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor European Journal of Organic Chemistry, 2015 (34). pp. 7433-7437. ISSN 1434-193X
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Official URL: http://doi.org/10.1002/ejoc.201501048
Related URL: http://dx.doi.org/10.1002/ejoc.201501048
Abstract
A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop–Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Wiley Online Library |
| ID Code: | 121942 |
| Deposited On: | 23 Jul 2021 09:17 |
| Last Modified: | 30 Jul 2021 07:52 |
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