Solution-Phase Synthesis of the Macrocyclic Core of Teixobactin

Dhara, Santu ; Gunjal, Vidya B. ; Handore, Kishor L. ; Srinivasa Reddy, D. (2016) Solution-Phase Synthesis of the Macrocyclic Core of Teixobactin European Journal of Organic Chemistry, 2016 (25). pp. 4289-4293. ISSN 1434-193X

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Official URL: http://doi.org/10.1002/ejoc.201600778

Related URL: http://dx.doi.org/10.1002/ejoc.201600778

Abstract

Towards the total chemical synthesis of the exceptionally potent antibiotic teixobactin, we synthesized the macrocyclic core of a natural product by using a solution-phase approach. The gramscale synthesis of l-allo-enduracididine and Shiina macrolactonization are highlights of the present disclosure.

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